Fri Dec 06 2024

111 articles - From Friday Nov 29 2024 to Friday Dec 06 2024

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Aliment Pharmacol Ther

Successful Amendment of an Existing Hepatitis B Screening Programme by a Guideline Recommended Hepatitis D Screening in the Primary Care Setting.

Retrospective data show insufficient anti-HDV screening in clinical routine. The prospective anti-HDV screening provides a blueprint for using existing hepatitis B virus screening programms for population-based HDV double reflex testing, provided that adequate logistical prerequisites are established.

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Am J Gastroenterol

ACG Clinical Guideline: Treatment of Helicobacter pylori Infection.

The CPG concludes with a discussion of proposed research priorities to address knowledge gaps and inform future management recommendations in patients with H. pylori infection from North America.

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J Hepatol

Metabolic Dysfunction and Alcohol-related Liver Disease (MetALD): Position statement by an expert panel on alcohol-related liver disease.

Additionally, metabolic dysfunction and alcohol use should be reassessed over time, especially after periods of changes in risk factor exposure. This approach could ensure a more accurate prognosis and effective management of SLD addressing both metabolic and alcohol-related factors.

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Meta-analysis

meta-analyses and systematic reviews

Gastroenterology

Fecal hemoglobin levels in prior negative screening and detection of colorectal neoplasia: a dose-response meta-analysis.

Our findings suggest that the risk of detecting colorectal neoplasia increases with prior f-Hb concentrations in negative tests, supporting the development of risk-stratified screening strategies based on these concentrations.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Black Race is Associated with Decreased Exposure to Advanced Therapies and Worse Outcomes in Individuals with Ulcerative Colitis.

Black individuals with UC are prescribed fewer disease-specific therapies compared to White individuals and have increased hospitalizations and mortality. Black individuals have higher rates of opioid prescriptions. Opioids have been associated with increased complication rates in inflammatory bowel disease. These trends are not seen in Asian individuals. This reveals critical disparities in the care of Black people with UC with opportunity for targeted interventions.

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Clinical Trial: Treatment of Functional Dyspepsia According to Subtype Compared With Empirical Proton Pump Inhibitor.

Initial treatment of FD according to subtype was not more effective than empirical PPI alone for up to 8 weeks. Further multicentre studies, with a larger sample size, are recommended to validate these findings.

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Coronary Artery Disease and Major Adverse Cardiovascular Events in People With Hepatic Steatosis at Low Atherosclerotic Cardiovascular Disease Risk.

Individuals with HS at ASCVD < 7.5% risk had similar CAD characteristics as patients without HS at < 7.5% ASCVD risk, yet experienced comparable MACE rates as those at ASCVD ≥ 7.5%.

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Early HBcrAg and Anti-HBc Levels Identify Patients at High Risk for Severe Flares After Nucleos(t)ide Analogue Cessation-A Pooled Analysis of Two Clinical Trials.

Higher HBcrAg, lower anti-HBc and higher HBcrAg/anti-HBc ratio at EOT and during the first weeks of post-treatment follow-up are associated with an increased risk of hepatic flares after NA withdrawal and could therefore potentially be used to select patients eligible for therapy cessation and to identify patients requiring retreatment.

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No Association Between Eosinophilic Oesophagitis and Oesophageal Cancer in US Adults: A Case-Control Study.

EoE is not associated with the development of oesophageal cancer in privately insured adults under 65 years old; co-incidence of EoE and oesophageal cancer is extremely rare. Additional studies are needed to confirm these findings and to evaluate whether they hold in older adults or over longer follow-up, and whether EoE might protect against oesophageal cancer.

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Am J Gastroenterol

Effect of Esophageal Dilation History on Efficacy Outcomes in Patients With Eosinophilic Esophagitis Receiving Budesonide Oral Suspension.

Esophageal dilation history may confound the association between histologic outcomes and dysphagia symptom or endoscopic efficacy outcomes in patients with EoE receiving swallowed corticosteroids.

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Endosc Int Open

Areas of improvement for colorectal cancer screening: Results of a screening initiative for 10,000 health care employees in Austria.

There is a serious gap between recommended standards and real-world CRC screening colonoscopy quality. Implementation of CRC screening should not only be accompanied by strategies to increase participation rates but focus on implementation of rigorous, mandatory colonoscopy quality assurance programs.

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Digital peroral pancreatoscopy to determine surgery for patients who have intraductal papillary mucinous neoplasms of the pancreas with mural nodules.

POPS-DS could be used to accurately detect malignancy in patients with MN-positive IPMN. Therefore, histocytological evaluation using POPS-DS can contribute to selection of patients for whom surgery would be appropriate.

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Dye-based chromoendoscopy versus i-scan virtual chromoendoscopy in long-standing ulcerative colitis: Multicenter prospective RCT.

However, use of i-scan VCE was associated with a lower false-positive rate and a significantly shorter procedure time compared with DCE. I-scan VCE, therefore, could be a valid replacement for DCE in UC surveillance colonoscopies.

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Enteroscopy-assisted ERCP in patients with surgically altered anatomy: Multicenter prospective registry (SAMISEN-B) using motorized spiral enteroscopy.

(clinicaltrials. gov: NCT05129449).

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Evaluating endoscopic ultrasound-guided tissue acquisition for diagnosis of small pancreatic neuroendocrine neoplasms.

EUS-TA showed adequate diagnostic sensitivity and grading agreement for p-NENs of al sizes, allowing for determination of appropriate treatment.

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Feasibility and benefit of decompressive percutaneous endoscopic gastrostomy (dPEG) in advanced cancer patients with malignant bowel obstruction.

However, the technical success rate is limited and needs to be improved. Prospective studies comparing endoscopic and computed tomography-guided procedures are needed to avoid unsuccessful procedures in patients with advanced cancer and limited life expectancy.

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Feasibility of newly designed rotatable sphincterotome for endoscopic sphincterotomy (with video).

We evaluated the feasibility of the newly designed r-sphincterotome using an experimental model. We believe that the findings from these experiments may contribute to easier and more precise sphincterotomies.

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Intraoperative bleeding model for swine gastric endoscopic submucosal dissection via heparinization.

High doses of heparin significantly increased intraoperative bleeding and hematoma during swine ESD.

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Low incidence of deep vein thrombosis after double-balloon endoscopy and colorectal submucosal dissection: Multicenter, prospective study.

This prospective study demonstrated that risk of DVT/PE following highly invasive endoscopic procedures including colorectal ESD and DBE is very low.

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Which is the better polyp detection metric: adenomas per colonoscopy or adenoma detection rate? A simulation modeling study.

Adjusting for patient and exam factors and/or using shrinkage techniques for lower-volume endoscopists can increase the correlation between TEA for both ADR and APC. For higher detection rates, APC offers more power than ADR in distinguishing differences in detection ability.

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Endoscopy

Hemospray as first-line treatment option for malignant gastrointestinal bleeding: A cost-utility analysis in the United Kingdom.

Initial treatment of MUGIB with TC-325 compared to SET is more effective (higher primary haemostasis and lower 30-day rebleeding) and cost-saving due to requiring fewer interventions, readmissions, and length of stay. Additional studies are needed to address model uncertainties in the follow-up management of these complex patients.

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Gastroenterology

ERBB2 comprehensive profiling and prognostication in Stage III Colon Cancer: Findings from PETACC8 and IDEA-France cohorts.

The molecular definition of ERBB2-status could represent a cost-effective alternative in stage III CC. ERBB2 alterations and low RNA expression significantly reduce TTR, highlighting the complex role of ERBB2.

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Multi-HCC: A practical model to prioritize patients with hepatocellular carcinoma on the liver transplant waiting list.

An urgency-based priority system for patients with HCC, similar to MELD for patients with chronic liver disease, is achievable with a parsimonious model incorporating AFP, MELD 3.0, and tumor size. This approach can be applied to the liver allocation system to prioritize patients with HCC and can inform decision-making regarding urgency weights for exception cases in the upcoming continuous distribution system.

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Preclinical protein signatures of Crohn's disease and ulcerative colitis: A nested case-control study within large population-based cohorts.

We identified protein signatures for predicting a future diagnosis of CD and UC, validated across independent cohorts. In the context of CD, the signature offers potential for early prediction.

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Gastrointest Endosc

A randomized controlled trial of a through the scope stiffening wire to increase the depth of insertion during double balloon enteroscopy.

The stiffening wire increased insertion depth and should be used when an abnormality cannot be reached with conventional technique.

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Creating a Standardized Tool for the Evaluation and Comparison of Artificial Intelligence-Based Computer-Aided Detection Programs in Colonoscopy: a Modified Delphi Approach.

This is the first reported international consensus statement of priority scoring metrics for CADe in colonoscopy. These scoring criteria should inform CADe software development and refinement. Future research should validate these metrics on a benchmark video data set to develop a validated scoring instrument.

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Stratification of risk for lymph node metastasis and long-term oncologic outcomes in patients initially treated by endoscopic resection for rectal neuroendocrine tumors.

The risk of LN metastasis increased significantly when the number of risk factors increased in patients with rectal NETs. Patients who initially underwent endoscopic resection for rectal NETs showed a favorable long-term oncologic outcome if salvage treatments were performed, depending on the stratification of their risk factors.

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Gut

Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator <i>POU2AF2</i>.

Background Common genetic variation at 11q23.1 is associated with colorectal cancer (CRC) risk, exerting local expression quantitative trait locus (cis-eQTL) effects on is the primary transcriptional activator of tuft cells with a tumour suppressive role in mouse models. We therefore implicate tuft cells as having a key tumour-protective role in the large bowel epithelium.

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Hepatology

Hepatic real-world outcomes with obeticholic acid in primary biliary cholangitis (HEROES): A trial emulation study design.

We identified a 63% reduced risk of hospitalization for hepatic decompensation, liver transplant, or death in OCA-treated versus non-OCA-treated individuals.

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Multimodal multiphasic pre-operative image-based deep-learning predicts hepatocellular carcinoma outcomes after curative surgery.

Recurr-NET accurately predicted HCC recurrence, out-performing MVI and clinical prediction scores respectively, highlighting its potential in pre-operative prognostication.

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Tumor-derived CCL2 drives tumor growth and immunosuppression in IDH1-mutant cholangiocarcinoma.

IDH1-mutant CCA is characterized by increased abundance of M2-like TAMs. Targeting CCL2 remodels the tumor immune microenvironment and improves outcomes in preclinical models of IDH1-mutant CCA, highlighting the role for myeloid-targeted immunotherapies in the treatment of this cancer.

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miRNAs in HCC, pathogenesis, and targets.

We also discuss the therapeutic and diagnostic potential of miRNAs and delivery approaches of miRNA drugs to overcome the limitations of current HCC treatment options. By thoroughly summarizing the roles of miRNAs in HCC, our goal is to advance the development of effective therapeutic drugs with minimal adverse effects and to establish precise tools for early diagnosis of HCC.

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J Hepatol

Utility of AI digital pathology as an aid for pathologists scoring fibrosis in MASH.

The use of AI DP enhances inter-rater reliability of fibrosis staging for MASH. This indicates that the SHG/TPEF-based AI DP tool is useful for assisting pathologists in assessing fibrosis, thereby enhancing clinical trial efficiency and reliability of fibrosis readouts in response to treatments.

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J Neurogastroenterol Motil

Clinical Characteristics of Patients With Proton Pump Inhibitor-refractory Globus.

Reduced proximal BI values compared to distal BI values suggest increased permeability in globus patients. Further studies with a larger cohort of refractory PPI patients and healthy volunteers are needed to explore these findings and their implications on globus etiology.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: Updated COVID-19 Boosters-Tailoring Protection for Patients With IBD.

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Endosc Int Open

How should the electrosurgical mode be optimized for endoscopic sphincterotomy?

Pubmed   Journal   ReadQx   PMC

Gastroenterology

Gut archaeal biomarkers in colorectal cancer prediction: a tale of opportunity and prudence.

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To look or not to look: A new score for stratifying patients at risk of developing HCC.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

2024 CME Information.

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Calendar of Courses, Symposiums and Conferences.

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Calendar of Courses, Symposiums and Conferences.

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Correction to COBALT: A Confirmatory Trial of Obeticholic Acid in Primary Biliary Cholangitis With Placebo and External Controls.

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Correction to: Utilization of Treat-to-Target Monitoring Colonoscopy After Treatment Initiation in the US-Based Study of a Prospective Adult Research Cohort With Inflammatory Bowel Disease.

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Endoscopic Ultrasound-Guided Gastrojejunostomy for Severe Duodenal Polyposis From Gardner Syndrome.

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Gastrohepatic Fistula Secondary to Metastatic Colon Cancer as a Rare Etiology of Upper Gastrointestinal Bleed.

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Malignant Myopericytoma Involving the Colon Presenting as Occult Blood Loss.

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Mucin Secretion From Appendiceal Lumen Detected by Colonoscopy: A Very Rare Presentation of a Low-Grade Appendiceal Mucinous Neoplasm.

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Optimizing Acute Variceal Bleeding Management: Abbreviated Therapy With Terlipressin and Antibiotics.

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Rare Pyloric Adenomas Characterized by Giant Circumferential Lesions in and Below the Cardia.

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Shared Decision Making in EoE.

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When Subtraction Wins, What Are the Considerations for Addition in Helicobacter pylori Eradication?

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Endoscopy

"The future of GI endoscopy…where are we going?"

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A self-made wire snare used in combination with a long transparent cap to remove a giant phytobezoar.

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Curved puncture technique using a flexible stainless-steel needle in endoscopic ultrasound-guided hepaticogastrostomy.

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Endoscopic extraction of a foreign body using a condom.

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Endoscopic full-thickness resection with local injection into tissue outside the capsule of a gastrointestinal stromal tumor.

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Endoscopic removal of a challenging gastric foreign body causing unexplained abdominal pain.

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Endoscopic retrieval of a huge gastric trichobezoar after thermally induced cutting with a hook knife.

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Endoscopic transcecal resection of a low grade appendiceal mucinous neoplasm.

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Endoscopy E-Videos - recently published.

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Exploration of the feasibility of the tunneling technique for colonic lesions originating from the muscularis propria.

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Exploring artificial intelligence-assisted diagnosis of esophageal squamous cell carcinoma: insights from a clinical trial.

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Modified overtube insertion technique to facilitate safe endoscopic cricopharyngeal myotomy for management of Zenker's diverticulum.

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Mucosal inverted closure of a post-gastric endoscopic submucosal dissection defect using grasping forceps with good rotatability and sharp claws.

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Prophylactic saline-immersion snare-tip vessel coagulation after colorectal endoscopic resection.

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Rescue endoscopic ultrasound-guided gastroenterostomy with closing of the duodenum in case of duodenal perforation.

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Sparse outer longitudinal muscle layer in peranal endoscopic myectomy: reinforcement of wound closure with peptide gel.

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Submucosal tunnel endoscopic resection for removal of deep-seated rectal gastrointestinal stromal tumor in the muscularis propria.

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Successful closure of a cholecystocolonic fistula due to cholecystitis using a clipping system.

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Successful closure of a delayed persistent duodenal perforation using endoscopic suturing after unsuccessful surgical intervention.

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The stability of a novel 0.035-inch guidewire facilitates endoscopic ultrasound-guided hepaticoduodenostomy.

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Underwater endoscopic submucosal dissection with nasal intubation using a small-bore tracheal tube for an early epiglottic lesion.

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Unlicensed stent use creating the need for additional procedures.

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Why is endoscopic reintervention easier using a braided metal stent than a laser-cut stent in stent-in-stent placement? A bench study.

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Gastroenterology

A Case of Cholestasis in an Adult Male: The Mystery of a Long-Unresolved Condition.

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Better Together: Implementing a Multidisciplinary Approach to Optimizing Diagnosis and Management of Crohn's Perianal Fistulas.

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Evaluation of LI-RADS 3 and 4 Lesions.

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Gastro Digest: The Revised REACH-B Model Predicts Hepatocellular Carcinoma in Patients with Chronic Hepatitis B.

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Incorporating a GI Dietitian into Your GI Practice.

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New agonists of the incretin/glucagon system for the treatment of metabolic dysfunction-associated steatohepatitis.

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Think beyond the typical!

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Gastrointest Endosc

Rescue Laparoscopy-Assisted Repositioning of a Misdeployed Metal Stent in the Peritoneum Following Endoscopic Ultrasound-Guided Hepaticogastrostomy (with video).

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Hepatology

Cover Image.

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Cover Image.

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Exchangeable Copper in the Danish Cohort of Patients with Wilson Disease.

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Hepatology highlights.

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Hepatology highlights.

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Information for Readers.

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Information for Readers.

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Instructions to Authors.

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Instructions to Authors.

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Reply: Quality indicators and the safety profile of endoscopic intervention in patients with bleeding esophageal varices.

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Table of contents.

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Table of contents.

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J Hepatol

Brain-to-gut control of fat absorption: Implications for metabolic liver diseases.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Letter: Critical Insights on a Nationwide Cohort Study of Inflammatory Bowel Disease, Histological Activity and Fracture Risk.

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Letter: Extending the Measurement of Inflammatory Bowel Disease Severity to Include Patient Important Outcomes-Authors' Reply.

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Letter: Extending the Measurement of Inflammatory Bowel Disease Severity to Include Patient Important Outcomes.

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Letter: Why Assessment of ChILI Severity Accurately Matters?

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Gastroenterology

Optimizing CT-P13 SC Use in IBD: ADA Formation, Comparative Efficacy, and Dose Adjustment Strategies.

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Gut

Primary prophylaxis in patients with high risk oesophageal varices to prevent oesophageal variceal bleeding (OVB)-The CAVARLY is stronger together!!

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Response letter to the editor.

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J Hepatol

A Comprehensive Framework for Investigating Oral-Gut Microbiome Dynamics: From Normal Variation to Pathological Changes.

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Do not leave any ambiguity: alcohol in any amount is harmful.

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Exploring the effects of serum G-CSF levels in acute-on-chronic liver failure (ACLF): Insights from a post-hoc analysis of the GRAFT study.

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Inclusion of Patients with Active Urinary Sediment in Treatment of Hepatorenal Syndrome.

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MASH Meets HBV: Age, Lifestyle, and the Untapped Role of Non-Immune Cells.

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Missing the forest for the trees: time to address stool microbial load and everything else that realistically matters in microbiome studies.

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Plasma metabolomics promises to facilitate precise prevention of MASH and mortality from liver disease.

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Poor long-term outcome in patients with porto-sinusoidal vascular disease (PSVD): fact or disease misclassification?

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Reconciling the apparently contrasting observational and genetic evidence on the association between MASLD and cardiovascular disease.

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